Applied Neuroscience - Irena Rektorová

Principal Investigator

Research areas

Main objectives

• Identify early diagnostic and prognostic biomarkers of Alzheimer’s disease/ Parkinson’s disease (AD/PD) (PI: I. Rektorová)
• Combine multimodal MRI/EEG and non-invasive brain stimulation (rTMS, tCDS) to modulate cognition and behaviour in AD/PD and schizophrenia
• Understand and control central and peripheral pain
• Identify immunopathological mechanisms of multiple sclerosis

Content of research

The main research focus is on study of early imaging, biochemical and genetic markers of neurodegenerative brain diseases (from an animal model to human studies), pathophysiological mechanisms for neuropathic pain, immunopathological mechanisms of multiple sclerosis, and cognitive and behavioural symptoms of Parkinson’s disease, Alzheimer’s disease and schizophrenia. We particularly use multimodal brain and spinal cord imaging alone or in combination with noninvasive brain stimulation such as repetitive transcranial magnetic stimulation (rTMS). rTMS utilizes rapid magnetic pulses applied over the scalp with a small hand-held coil to induce precisely timed and localized electrical currents within the cortex of human subjects. It provides a non-invasive tool for studying pathophysiological mechanisms of various motor, cognitive and neuropsychiatric symptoms and may induce treatment effects. Other techniques have also been employed including quantitative sensory testing (QST), dynamic QST, and immunohistochemistry of dermal nerve fibers using skin biopsy. 

 

list / cards

SELECTED PUBLICATIONS

2017

• ANDERKOVA, L; BARTON, M; REKTOROVA, I, 2017:Striato-cortical Connections in Parkinson's and Alzheimer's Diseases: Relation to Cognition. MOVEMENT DISORDERS 32 (6), p. 917 - 921.
• BRABENEC, L; MEKYSKA, J; GALAZ, Z; ZVONCAK, V; KISKA, T; MUCHA, J; SMEKAL, Z; KOSTALOVA, M; REKTOROVA, I, 2017:Effects of non-invasive brain stimulation of the superior temporal gyrus on motor speech disorder in Parkinson's disease. EUROPEAN JOURNAL OF NEUROLOGY 24 , p. 478 - 478.
• KHAIRNAR, A; RUDA-KUCEROVA, J; SZABO, N; DRAZANOVA, E; ARAB, A; HUTTER-PAIER, B; NEDDENS, J; LATTA, P; STARCUK, Z; REKTOROVA, I, 2017:Early and progressive microstructural brain changes in mice overexpressing human alpha-Synuclein detected by diffusion kurtosis imaging. BRAIN BEHAVIOR AND IMMUNITY 61 , p. 197 - 208.
• KLIMES, P; JURAK, P; HALAMEK, J; BOCKOVA, M; DAMBORSKA, A; DOLEZALOVA, I; STILLOVA, K; BALAZ, M; DANIEL, P; BRAZDIL, M; REKTOR, I, 2017:INTRATHALAMIC HIGH-FREQUENCY EEG CAN PREDICT DEEP BRAIN STIMULATION EFFICACY IN EPILEPSY. EPILEPSIA 58 , p. S187 - S187.
• MORATALLA, R; KHAIRNAR, A; SIMOLA, N; GRANADO, N; GARCIA-MONTES, JR; PORCEDDU, PF; TIZABI, Y; COSTA, G; MORELLI, M, 2017:Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms. PROGRESS IN NEUROBIOLOGY 155 , p. 149 - 170.
• RAPUTOVA, J; SROTOVA, I; VLCKOVA, E; SOMMER, C; UCEYLER, N; BIRKLEIN, F; RITTNER, HL; REBHORN, C; ADAMOVA, B; KOVALOVA, I; NEKVAPILOVA, EK; FORER, L; BELOBRADKOVA, J; OLSOVSKY, J; WEBER, P; DUSEK, L; JARKOVSKY, J; BEDNARIK, J, 2017:Sensory phenotype and risk factors for painful diabetic neuropathy: a cross-sectional observational study. PAIN 158 (12), p. 2340 - 2353.
• REKTOROVA, I, 2017:IAPRD annual report-2016. PARKINSONISM & RELATED DISORDERS 40 , p. 85 - 86.
• USTOHAL, L; MAYEROVA, M; HUBLOVA, V; KUCEROVA, HP; CESKOVA, E; KASPAREK, T, 2017:Risperidone increases the cortical silent period in drug-naive patients with first-episode schizophrenia: A transcranial magnetic stimulation study. JOURNAL OF PSYCHOPHARMACOLOGY 31 (4), p. 500 - 504.

2016

• CESKOVA, E, 2016:Current pharmacotherapy of depression - focused on multimodal/multifunctional antidepressants. EXPERT OPINION ON PHARMACOTHERAPY 17 (14), p. 1835 - 1837.
• ELFMARKOVA, N; GAJDOS, M; MRACKOVA, M; MEKYSKA, J; MIKL, M; REKTOROVA, I, 2016:Impact of Parkinson's disease and levodopa on resting state functional connectivity related to speech prosody control. PARKINSONISM & RELATED DISORDERS 22 , p. S52 - S55.
• GAJDOS, M; MIKL, M; MARECEK, R, 2016:Mask_explorer: A tool for exploring brain masks in fMRI group analysis. COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE 134 , p. 155 - 163.
• GALAZ, Z; MEKYSKA, J; MZOUREK, Z; SMEKAL, Z; REKTOROVA, I; ELIASOVA, I; KOSTALOVA, M; MRACKOVA, M; BERANKOVA, D, 2016:Prosodic analysis of neutral, stress-modified and rhymed speech in patients with Parkinson's disease. COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE 127 , p. 301 - 317.
• LOSAK, J; HUTTLOVA, J; LIPOVA, P; MARECEK, R; BARES, M; FILIP, P; ZUBOR, J; USTOHAL, L; VANICEK, J; KASPAREK, T, 2016:Predictive Motor Timing and the Cerebellar Vermis in Schizophrenia: An fMRI Study. SCHIZOPHRENIA BULLETIN 42 (6), p. 1517 - 1527.
• MARECEK, R; LAMOS, M; MIKL, M; BARTON, M; FAJKUS, J; REKTOR, I; BRAZDIL, M, 2016:What can be found in scalp EEG spectrum beyond common frequency bands. EEG-fMRI study. JOURNAL OF NEURAL ENGINEERING 13 (4)
• REKTOROVA, I; MEKYSKA, J; JANOUSOVA, E; KOSTALOVA, M; ELIASOVA, I; MRACKOVA, M; BERANKOVA, D; NECASOVA, T; SMEKAL, Z; MARECEK, R, 2016:Speech prosody impairment predicts cognitive decline in Parkinson's disease. PARKINSONISM & RELATED DISORDERS 29 , p. 90 - 95.
• SHAW, DJ; MARECEK, R; GROSBRAS, MH; LEONARD, G; PIKE, GB; PAUS, T, 2016:Co-ordinated structural and functional covariance in the adolescent brain underlies face processing performance. SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE 11 (4), p. 556 - 568.
• SVOBODOVA, M; CRHA, I; NEKVAPILOVA, E; PODBORSKA, M; SROTOVA, I; VLCKOVA, E; STOURAC, P; BEDNARIK, J, 2016:Levels of serum anti-mullerian hormone in women with early stage of relapsing-remitting multiple sclerosis. MULTIPLE SCLEROSIS JOURNAL 22 , p. 437 - 438.

2015

• DROTAR, P; MEKYSKA, J; REKTOROVA, I; MASAROVA, L; SMEKAL, Z; FAUNDEZ-ZANUY, M, 2015:Decision Support Framework for Parkinson's Disease Based on Novel Handwriting Markers. IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING 23 (3), p. 508 - 516.
• LABBE, C; OGAKI, K; LORENZO-BETANCOR, O; SOTO-ORTOLAZA, AI; WALTON, RL; RAYAPROLU, S; FUJIOKA, S; MURRAY, ME; HECKMAN, MG; PUSCHMANN, A; MCCARTHY, A; LYNCH, T; SIUDA, J; OPALA, G; RUDZINSKA, M; KRYGOWSKA-WAJS, A; BARCIKOWSKA, M; CZYZEWSKI, K; SANOTSKY, Y; REKTOROVA, I; MCLEAN, PJ; RADEMAKERS, R; ERTEKIN-TANER, N; HASSAN, A; AHLSKOG, JE; BOEVE, BF; PETERSEN, RC; MARAGANORE, DM; ADLER, CH; FERMAN, TJ; PARISI, JE; GRAFF-RADFORD, NR; UITTI, RJ; WSZOLEK, ZK; DICKSON, DW; ROSS, OA, 2015:Role for the microtubule-associated protein tau variant p.A152T in risk of alpha-synucleinopathies. NEUROLOGY 85 (19), p. 1680 - 1686.
• SHAW, D J; MARECEK, R; BRAZDIL, M., 2015:Structural co-variance mapping delineates medial and medio-lateral temporal networks in déjà vu. Brain Imaging and Behaviour 10 (4), p. 1068 - 1079.

2014

• CESKOVA, E; PRIKRYL, R; LIBIGER, J, 2014:Gender differences in the pharmacotherapy of schizophrenia. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY 17 , p. 66 - 66.
• JURA, R; SROTOVA, I; JANKU, P; ADAMOVA, B, 2014:Post-partum posterior reversible encephalopathy syndrome in a pre-eclamptic woman with twin pregnancy. EUROPEAN JOURNAL OF NEUROLOGY 21 , p. 575 - 575.
• KRAJCOVICOVA, L; MARECEK, R; MIKL, M; REKTOROVA, I, 2014:Disruption of Resting Functional Connectivity in Alzheimer's Patients and At-Risk Subjects. CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS 14 (10)
• KRAJCOVICOVA, L; MIKL, M; MARECEK, R; REKTOROVA, I, 2014:Disturbed Default Mode Network Connectivity Patterns in Alzheimer's Disease Associated with Visual Processing. JOURNAL OF ALZHEIMERS DISEASE 41 (4), p. 1229 - 1238.
• MAYEROVA, M; USTOHAL, L; STEHNOVA, I; PRIKRYL, R; CESKOVA, E; KASPAREK, T, 2014:Early response to risperidone treatment in the first episode of schizophrenia (FES) patients and its predictive value to subsequent response. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY 17 , p. 147 - 148.
• PRIKRYL, R; USTOHAL, L; KUCEROVA, HP; KASPAREK, T; JARKOVSKY, J; HUBLOVA, V; VRZALOVA, M; CESKOVA, E, 2014:Repetitive transcranial magnetic stimulation reduces cigarette consumption in schizophrenia patients. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 49 , p. 30 - 35.
• REKTOROVA, I, 2014:Resting-State Networks in Alzheimer's Disease and Parkinson's Disease. NEURODEGENERATIVE DISEASES 13 (42065), p. 186 - 188.
• REKTOROVA, I; BIUNDO, R; MARECEK, R; WEIS, L; AARSLAND, D; ANTONINI, A, 2014:Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients. PLOS ONE 9 (1)
• REKTOROVA, I; KRAJCOVICOVA, L; MARECEK, R; NOVAKOVA, M; MIKL, M, 2014:Default Mode Network Connectivity Patterns associated with Visual Processing at Different Stages of Parkinson's Disease. JOURNAL OF ALZHEIMERS DISEASE 42 , p. S217 - S228.
• USTOHAL, L; PRIKRYL, R; HUBLOVA, V; MAYEROVA, M; KUCEROVA, HP; CESKOVA, E; KASPAREK, T, 2014:Severe acute dystonia/akathisia after paliperidone palmitate application - a case study. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY 17 (2), p. 341 - 342.
• VLCKOVA, E; SROTOVA, I; KINCOVA, S; PRAKSOVA, P; ADAMOVA, B; BEDNARIK, J, 2014:Evaluation of sensory and pain perception and its central modulation in chronic low back pain. EUROPEAN JOURNAL OF NEUROLOGY 21 , p. 603 - 603.

2013

• BRAZDIL, M; JANECEK, J; KLIMES, P; MARECEK, R; ROMAN, R; JURAK, P; CHLADEK, J; DANIEL, P; REKTOR, I; HALAMEK, J; PLESINGER, F; JIRSA, V, 2013:On the Time Course of Synchronization Patterns of Neuronal Discharges in the Human Brain during Cognitive Tasks. PLOS ONE 8 (5)
• GESCHEIDT, T; MARECEK, R; MIKL, M; CZEKOOVA, K; URBANEK, T; VANICEK, J; SHAW, DJ; BARES, M, 2013:Functional anatomy of outcome evaluation during Iowa Gambling Task performance in patients with Parkinson's disease: an fMRI study. NEUROLOGICAL SCIENCES 34 (12), p. 2159 - 2166.
• KASPAREK, T; PRIKRYL, R; REHULOVA, J; MARECEK, R; MIKL, M; PRIKRYLOVA, H; VANICEK, J; CESKOVA, E, 2013:Brain functional connectivity of male patients in remission after the first episode of schizophrenia. HUMAN BRAIN MAPPING 34 (3), p. 726 - 737.
• PRIKRYL, R; USTOHAL, L; KUCEROVA, HP; KASPAREK, T; VENCLIKOVA, S; VRZALOVA, M; CESKOVA, E, 2013:A detailed analysis of the effect of repetitive transcranial magnetic stimulation on negative symptoms of schizophrenia: A double-blind trial. SCHIZOPHRENIA RESEARCH 149 (42064), p. 167 - 173.
• SHAW, DJ; CZEKOOVA, K; CHROMEC, J; MARECEK, R; BRAZDIL, M, 2013:Copying You Copying Me: Interpersonal Motor Co-Ordination Influences Automatic Imitation. PLOS ONE 8 (12), p. e84820 - .
• ZELINKOVA, J; SHAW, DJ; MARECEK, R; MIKL, M; URBANEK, T; PETERKOVA, L; ZAMECNIK, P; BRAZDIL, M, 2013:Superior temporal sulcus and social cognition in dangerous drivers. NEUROIMAGE 83 , p. 1024 - 1030.

2012

• BURSOVA, S; DUBOVY, P; VLCKOVA-MORAVCOVA, E; NEMEC, M; KLUSAKOVA, I; BELOBRADKOVA, J; BEDNARIK, J, 2012:Expression of growth-associated protein 43 in the skin nerve fibers of patients with type 2 diabetes mellitus. JOURNAL OF THE NEUROLOGICAL SCIENCES 315 (42036), p. 60 - 63.
• CESKOVA, E, 2012:Optimizing treatment with risperidone long-acting injections. ACTA PSYCHIATRICA SCANDINAVICA 126 (6), p. 479 - 480.
• DIVISOVA, S; VLCKOVA, E; HNOJCIKOVA, M; SKORNA, M; NEMEC, M; DUBOVY, P; DUSEK, L; JARKOVSKY, J; BELOBRADKOVA, J; BEDNARIK, J, 2012:Prediabetes/early diabetes-associated neuropathy predominantly involves sensory small fibres. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM 17 (3), p. 341 - 350.
• GESCHEIDT, T; CZEKOOVA, K; URBANEK, T; MARECEK, R; MIKL, M; KUBIKOVA, R; TELECKA, S; ANDRLOVA, H; HUSAROVA, I; BARES, M, 2012:Iowa Gambling Task in patients with early-onset Parkinson's disease: strategy analysis. NEUROLOGICAL SCIENCES 33 (6), p. 1329 - 1335.
• MITASOVA, A., KOSTALOVA, M., BEDNARIK, J., MICHALCAKOVA, R., KASPAREK, T., BALABANOVA, P., DUSEK, L., VOHANKA, S., ELY, E., W., 2012:Post-stroke delirium incidence and outcomes: Validation of the confusion assessment method for the intensive care unit (CAM-ICU). Critical Care Medicine 40 (2), p. 484 - 490.
• REKTOR, I; GOLDEMUND, D; BEDNARIK, P; SHEARDOVA, K; MICHALKOVA, Z; TELECKA, S; DUFEK, M; REKTOROVA, I, 2012:Impairment of Brain Vessels May Contribute to Mortality in Patients With Parkinson's Disease. MOVEMENT DISORDERS 27 (9), p. 1168 - 1172.
• REKTOROVA, I; KRAJCOVICOVA, L; MARECEK, R; MIKL, M, 2012:Default Mode Network and Extrastriate Visual Resting State Network in Patients with Parkinson's Disease Dementia. NEURODEGENERATIVE DISEASES 10 (42095), p. 232 - 237.
• SORBI, S; HORT, J; ERKINJUNTTI, T; FLADBY, T; GAINOTTI, G; GURVIT, H; NACMIAS, B; PASQUIER, F; POPESCU, BO; REKTOROVA, I; RELIGA, D; RUSINA, R; ROSSOR, M; SCHMIDT, R; STEFANOVA, E; WARREN, JD; SCHELTENS, P, 2012:EFNS-ENS Guidelines on the diagnosis and management of disorders associated with dementia. EUROPEAN JOURNAL OF NEUROLOGY 19 (9), p. 1159 - +.

2011

• REKTOR, I; TOMCIK, J; MIKL, M; MARECEK, R; BRAZDIL, M; REKTOROVA, I, 2011:ASSOCIATION BETWEEN BASAL GANGLIA AND LARGE SCALE BRAIN NETWORKS IN EPILEPSY. EPILEPSIA 52 , p. 175 - 176.

GRANTY

• Non-coding RNAs in neurogenic and neuropathic pain mechanisms and their application for riskassessment, patient stratification and personalised pain medicine (602133), FP7 - Cooperation - Health, 2013 - 2017
• Pre-clinical genotype-phenotype predictors of Alzheimer's disease and other dementia (237250), EU Joint Programme - Neurodegenerative Disease Research (JPND), 2014 - 2016
• Identification of MRI based imaging biomarker in earlier detection of neuronal changes in animal models of Parkinson’s disease (4SGA8588), South Moravian Region - SoMoPro, 2015 - 2016
• Biomarkers for Alzheimer’s disease and Parkinson’s disease, EU Joint Programme - Neurodegenerative Disease Research (JPND), 2012 - 2015
• Multi-centre cohort-studies in Lewy-body dementia: Challenges in harmonizing different clinical and biomarker protocols, EU Joint Programme - Neurodegenerative Disease Research (JPND), 2014 - 2015
• Effect of intensive dance-exercise intervention on cognition and brain plasticity in healthy seniors and patients with mild cognitive impairment (15-33854A), Ministry of Health - Health research agency, 2015 - 2018
• Speech, its impairment and cognitive performance in Parkinson's disease (NT/13499), Internal grant agency - Ministry of Health, 2012 - 2015
• Specific characteristics of neuropathic pain of central and peripheral type (NT/13523), Internal grant agency - Ministry of Health, 2012 - 2015

                    

PLANNED RESEARCH INFRASTRUCTURE

Core Facility

The research group will be one of the principal users of the equipment available within CEITEC Molecular and Functional Imaging Core Facility.

CURRENT RESEARCH INFRASTRUCTURE

• Two whole-body MR scanners Siemens Magnetom Prisma 3T
• High density MR compatible EEG system (EGI Net Amps 400)
• 32 channels MR compatible EEG/ExG system (Brain Products Brain AMP MR)
• MR compatible ExG system (Brain Products Brain AMP ExG MR)
• rTMS system with frameless stereotaxy (Deymed DuoMag XT rTMS + Brainsight TMS Navigation)
• PATHWAY system 

rTMS system with frameless stereotaxy