Orthopaedics and Surgery - Pavel Proks

Research areas

• Small animal orthopaedics
• Bone and joint surgery
• Arthroscopy

Main objectives

• To obtain novel information on mechanisms of infectious diseases in domestic animals.
• Definition of the role of host genetics in infectious diseases.

Content of research

Analysis of the causes, mechanisms and spread of infectious diseases in domestic animals

The main objective is to evaluate the clinical manifestations and to make analyses of the causes of infections in surgically treated bone and joint diseases in model animals. Despite high quality care in small animal orthopaedics, we encounter, in a certain number of patients, the development of infectious disease. The aim of this study will be to analyse the causes of infections of bones and joints in surgically treated model animals and based on the obtained results, to contribute to possible reduction of infection complications in operated patients in veterinary and human medicine.

Host genetics and comparative immugenomics

The objective is to evaluate characteristics of clinical manifestations of bone and joint infections in relation to surgical procedures in animal models for purposes of genetic analysis.

 

list / cards

SELECTED PUBLICATIONS

2016

• SPONER, JE; SPONER, J; NOVAKOVA, O; BRABEC, V; SEDO, O; ZDRAHAL, Z; COSTANZO, G; PINO, S; SALADINO, R; DI MAURO, E, 2016:Emergence of the First Catalytic Oligonucleotides in a Formamide-Based Origin Scenario. CHEMISTRY-A EUROPEAN JOURNAL 22 (11), p. 3572 - 3586.

2014

• AMLER, E; FILOVA, E; BUZGO, M; PROSECKA, E; RAMPICHOVA, M; NECAS, A; NOOEAID, P; BOCCACCINI, AR, 2014:Functionalized nanofibers as drug-delivery systems for osteochondral regeneration. NANOMEDICINE 9 (7), p. 1083 - 1094.

2011

• PROSECKA, E; RAMPICHOVA, M; VOJTOVA, L; TVRDIK, D; MELCAKOVA, S; JUHASOVA, J; PLENCNER, M; JAKUBOVA, R; JANCAR, J; NECAS, A; KOCHOVA, P; KLEPACEK, J; TONAR, Z; AMLER, E, 2011:Optimized conditions for mesenchymal stem cells to differentiate into osteoblasts on a collagen/hydroxyapatite matrix. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 99A (2), p. 307 - 315.

2010

• NECAS, A; PLANKA, L; SRNEC, R; CRHA, M; HLUCILOVA, J; KLIMA, J; STARY, D; KREN, L; AMLER, E; VOJTOVA, L; JANCAR, J; GAL, P, 2010:Quality of Newly Formed Cartilaginous Tissue in Defects of Articular Surface after Transplantation of Mesenchymal Stem Cells in a Composite Scaffold Based on Collagen I with Chitosan Micro- and Nanofibres. PHYSIOLOGICAL RESEARCH 59 (4), p. 605 - 614.
• NECAS, A; PROKS, P; URBANOVA, L; SRNEC, R; STEHLIK, L; CRHA, M; RAUSER, P; PLANKA, L; AMLER, E; VOJTOVA, L; JANCAR, J, 2010:Radiographic Assessment of Implant Failures of Titanium 3.5 LCP vs. 4.5 LCP Used for Flexible Bridging Osteosynthesis of Large Segmental Femoral Diaphyseal Defects in a Miniature Pig Model. ACTA VETERINARIA BRNO 79 (4), p. 599 - U101.
• NECAS, A; PROKS, P; URBANOVA, L; SRNEC, R; STEHLIK, L; CRHA, M; RAUSER, P; PLANKA, L; JANOVEC, J; DVORAK, M; AMLER, E; VOJTOVA, L; JANCAR, J, 2010:Healing of Large Segmental Bone Defect after Implantation of Autogenous Cancellous Bone Graft in Comparison to Hydroxyapatite and 0.5% Collagen Scaffold Combined with Mesenchymal Stem Cells. ACTA VETERINARIA BRNO 79 (4), p. 607 - U108.

2009

• JANCAR, J; VOJTOVA, L; NECAS, A; SRNEC, R; URBANOVA, L; CRHA, M, 2009:Stability of Collagen Scaffold Implants for Animals with Iatrogenic Articular Cartilage Defects. ACTA VETERINARIA BRNO 78 (4), p. 643 - U107.

GRANTY

• Synthesis of new biomaterials and preparation of stem cell derived cells, and their aplications in for the treatment of diseases affecting human tissues derived from mesoderm: cartilage, bone, ligament and meniscus (2B06130), MEYS - Health and quality of life, 2006 - 2011

CURRENT RESEARCH INFRASTRUCTURE

The laboratories are currently fully equipped for the planned surgical procedures in model animals (operating theatres, surgical equipment, instrumentation, sterilisation, anaesthesia machines etc.).