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Structural Biology Seminar Series: The real RNAi - a Tale of Naughty Mice

Structural Biology Seminar Series: The real RNAi - a Tale of Naughty Mice

You are cordially invited to the lecture "The real RNAi - a Tale of Naughty Mice" delivered by Dr. Petr Svoboda, Institute of Molecular Genetics of the ASCR, v. v. i.

WHEN: Thursday, November 21, from 14:00
WHERE: seminar room 1.32, building A11, University Campus Bohunice, Brno

Abstract:

Our earlier study revealed robust production of short interfering RNAs(siRNAs) in the oocyte but not in somatic tissues in the mouse. We now report that growing mouse oocytes express a unique, N-terminally truncated isoform of Dicer, the small RNA-producing enzyme. Our data show that this Dicer isoform is responsible for increased production of endogenous siRNAs in the oocyte. The oocyte-specific Dicer isoform is the first evidence for molecular divergence of mammalian miRNA and RNAi mechanisms. Notably, production of oocyte-specific Dicer is controlled by a rodent-specific retrotransposon. This fact has interesting implications regarding evolution and conservation of RNA silencing pathways in animals.
 
Poster to download can be found HERE.
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