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Seminar: Single Molecule Analysis of Biological Mechanisms

SPEAKER: Dr. Andrea Candelli (Lumicks, Amsterdam, NL)
TOPIC: C-Trap - optical tweezers combined with confocal microscopy/STED nanoscopy - technology and applications
WHEN: Thursday, November 9, 2017, at 13:00
WHERE: Seminary room, building A3, University Campus Bohunice

 

Abstract:

Single-molecule technologies offer an exciting opportunity to study protein function and activity in real-time and at the single-molecule level. Here, we present our efforts for further enabling discoveries in the field of biology and biophysics using both the combination of optical tweezers with single-molecule fluorescence microscopy (C Trap).

We show the latest applications of these technologies that can enhance our understanding not only in the field of DNA/RNA-protein interactions but also in the fields of molecular motors, protein folding/unfolding, cell membranes and genome structure and organization. These experiments show that the technological advances in hybrid single-molecule methods can be turned into an easy-to-use and stable instrument that has the ability to open up new venues in many research areas.

Invitation with abstract is HERE

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