Marek Mráz, M.D., PhD

2017

• BENCUROVA, P; BALOUN, J; MUSILOVA, K; RADOVA, L; TICHY, B; PAIL, M; ZEMAN, M; BRICHTOVA, E; HERMANOVA, M; POSPISILOVA, S; MRAZ, M; BRAZDIL, M, 2017:MicroRNA and mesial temporal lobe epilepsy with hippocampal sclerosis: Whole miRNome profiling of human hippocampus. EPILEPSIA 58 (10), p. 1782 - 1793.
• PAVLASOVA, G; BORSKY, M; SVOBODOVA, V; MUSILOVA, K; CERNA, K; SEDA, V; OSICKOVA, J; BRYCHTOVA, Y; DOUBEK, M; POSPISILOVA, S; MAYER, J; MRAZ, M, 2017:BCR SIGNALLING PROFICIENT CHRONIC LYMPHOCYTIC LEUKAEMIA B CELLS ARE PRONE TO RITUXIMAB MEDIATED ELIMINATION IN VIVO. HAEMATOLOGICA 102 , p. 412 - 412.
• PAVLASOVA, G; MUSILOVA, K; SEDA, V; CERNA, K; VOJACKOVA, E; SVOBODOVA, V; MRAZ, M, 2017:The identification of combinatorial therapeutic approaches with BCR inhibitors in B cell malignancies. MOLECULAR CANCER THERAPEUTICS 16 (10)

2016

• PAVLASOVA, G; BORSKY, M; SEDA, V; CERNA, K; OSICKOVA, J; DOUBEK, M; MAYER, J; CALOGERO, R; POSPISILOVA, S; DAVIDS, M; BROWN, J; MRAZ, M, 2016:IBRUTINIB INHIBITS CD20 UP-REGULATION ON CLL B CELLS MEDIATED BY THE CXCR4/SDF-1 AXIS. HAEMATOLOGICA 101 , p. 47 - 47.
• PAVLASOVA, G; BORSKY, M; SEDA, V; CERNA, K; OSICKOVA, J; DOUBEK, M; MAYER, J; CALOGERO, R; TRBUSEK, M; POSPISILOVA, S; DAVIDS, MS; KIPPS, TJ; BROWN, JR; MRAZ, M, 2016:Ibrutinib inhibits CD20 upregulation on CLL B cells mediated by the CXCR4/SDF-1 axis. BLOOD 128 (12), p. 1609 - 1613.

2015

• DOLEZALOVA D; MRAZ M; HAMPL A, 2015:miRNA in Embryonic Stem Cells. In MICRORNA IN REGENERATIVE MEDICINE (book chapter)
• MALCIKOVA, J; STANO-KOZUBIK, K; TICHY, B; KANTOROVA, B; PAVLOVA, S; TOM, N; RADOVA, L; SMARDOVA, J; PARDY, F; DOUBEK, M; BRYCHTOVA, Y; MRAZ, M; PLEVOVA, K; DIVISKOVA, E; OLTOVA, A; MAYER, J; POSPISILOVA, S; TRBUSEK, M, 2015:Detailed analysis of therapy-driven clonal evolution of TP53 mutations in chronic lymphocytic leukemia. LEUKEMIA 29 (4), p. 877 - 885.
• MUSILOVA, K; MRAZ, M, 2015:MicroRNAs in B-cell lymphomas: how a complex biology gets more complex. LEUKEMIA 29 (5), p. 1004 - 1017.
• PAVLASOVA, G; SEDA, V; BORSKY, M; CERNA, K; OSICKOVA, J; MAYER, J; POSPISILOVA, S; DAVIDS, MS; BROWN, JR; MRAZ, M, 2015:Microenvironmental Interactions up-Regulate CD20 Expression in CLL B Cells through the CXCR4/SDF-1 Axis: Implications for CD20-Targeting Antibodies and the Use of BCR-Inhibitors in Combination. BLOOD 126 (23)
• SEDA, V; MRAZ, M, 2015:B-cell receptor signalling and its crosstalk with other pathways in normal and malignant cells. EUROPEAN JOURNAL OF HAEMATOLOGY 94 (3), p. 193 - 205.
• TOM, N; MALCIKOVA, J; RADOVA, L; KANTOROVA, B; PARDY, F; PAVLOVA, S; PAL, K; MRAZ, M; TICHY, B; DOUBEK, M; BRYCHTOVA, Y; PLEVOVA, K; MAYER, J; TRBUSEK, M; POSPISILOVA, S, 2015:MUTATIONS IN THE TP53 GENE SHOW FEATURES OF SOMATIC HYPERMUTATION PROCESS WITH PROMINENT DIFFERENCE BETWEEN IGHV MUTATED AND UNMUTATED CHRONIC LYMPHOCYTIC LEUKEMIA. HAEMATOLOGICA 100 , p. 224 - 225.

2014

• CUI, B; CHEN, LG; ZHANG, SP; MRAZ, M; FECTEAU, JF; YU, J; GHIA, EM; ZHANG, L; BAO, L; RASSENTI, LZ; MESSER, K; CALIN, GA; CROCE, CM; KIPPS, TJ, 2014:MicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemia. BLOOD 124 (4), p. 546 - 554.
• MRAZ, M; CHEN, LG; RASSENTI, LZ; GHIA, EM; LI, HY; JEPSEN, K; SMITH, EN; MESSER, K; FRAZER, KA; KIPPS, TJ, 2014:miR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1. BLOOD 124 (1), p. 84 - 95.

2013

• MRAZ, M; KIPPS, TJ, 2013:MicroRNAs and B cell receptor signaling in chronic lymphocytic leukemia. LEUKEMIA & LYMPHOMA 54 (8), p. 1836 - 1839.

2012

• DOLEZALOVA, D; MRAZ, M; BARTA, T; PLEVOVA, K; VINARSKY, V; HOLUBCOVA, Z; JAROS, J; DVORAK, P; POSPISILOVA, S; HAMPL, A, 2012:MicroRNAs Regulate p21(Waf1/Cip1) Protein Expression and the DNA Damage Response in Human Embryonic Stem Cells. STEM CELLS 30 (7), p. 1362 - 1372.
• MRAZ, M; DOLEZALOVA, D; PLEVOVA, K; KOZUBIK, KS; MAYEROVA, V; CERNA, K; MUSILOVA, K; TICHY, B; PAVLOVA, S; BORSKY, M; VERNER, J; DOUBEK, M; BRYCHTOVA, Y; TRBUSEK, M; HAMPL, A; MAYER, J; POSPISILOVA, S, 2012:MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia. BLOOD 119 (9), p. 2110 - 2113.
• MRAZ, M; POSPISILOVA, S, 2012:MicroRNAs in chronic lymphocytic leukemia: from causality to associations and back. EXPERT REVIEW OF HEMATOLOGY 5 (6), p. 579 - 581.

2011

• MRAZ, M; ZENT, CS; CHURCH, AK; JELINEK, DF; WU, XS; POSPISILOVA, S; ANSELL, SM; NOVAK, AJ; KAY, NE; WITZIG, TE; NOWAKOWSKI, GS, 2011:Bone marrow stromal cells protect lymphoma B-cells from rituximab-induced apoptosis and targeting integrin alpha-4-beta-1 (VLA-4) with natalizumab can overcome this resistance. BRITISH JOURNAL OF HAEMATOLOGY 155 (1), p. 53 - 64.
• TRBUSEK, M; SMARDOVA, J; MALCIKOVA, J; SEBEJOVA, L; DOBES, P; SVITAKOVA, M; VRANOVA, V; MRAZ, M; FRANCOVA, HS; DOUBEK, M; BRYCHTOVA, Y; KUGLIK, P; POSPISILOVA, S; MAYER, J, 2011:Missense Mutations Located in Structural p53 DNA-Binding Motifs Are Associated With Extremely Poor Survival in Chronic Lymphocytic Leukemia. JOURNAL OF CLINICAL ONCOLOGY 29 (19), p. 2703 - 2708.
• VARGOVA, K; CURIK, N; BURDA, P; BASOVA, P; KULVAIT, V; POSPISIL, V; SAVVULIDI, F; KOKAVEC, J; NECAS, E; BERKOVA, A; OBRTLIKOVA, P; KARBAN, J; MRAZ, M; POSPISILOVA, S; MAYER, J; TRNENY, M; ZAVADIL, J; STOPKA, T, 2011:MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia. BLOOD 117 (14), p. 3816 - 3825.

2009

• MRAZ, M., MALINOVA, K., KOTASKOVA, J., PAVLOVA, S., TICHY, B., MALCIKOVA, J., STANO-KOZUBIK, K., SMARDOVA, J., BRYCHTOVA, Y., DOUBEK, M., TRBUSEK, M., MAYER, J., POSPISILOVA, S., 2009:miR-34a, miR-29c and miR-17-5p are downregulated in CLL patients with TP53 abnormalities. Leukemia 23 (6), p. 1159 - 1163.

Office 1:

Masarykova univerzita - CEITEC MU Kamenice 753/5, Brno, 625 00, office bud. A35/216