Innate immunity and inflammation are central to human health. This was stated succinctly by the Nobel Laureate David Baltimore in 2011: ‘Autoimmunity, cancer and metabolic diseases are all secondary to chronic inflammation. This places inflammation at the heart of modern medicine’. The ‘Damage Model’ of Polly Matzinger proposes that innate immunity does not response to pathogens but responds to danger as defined by cellular damage. Therefore different cellular stresses can cause cellular damage, accidently triggering innate immunity which manifests itself as an autoimmune disease.
For many years my group has studied ADARs that convert adenosine to inosine in dsRNA. In 2014 we were the first to demonstrate that inosine in cellular RNA allows the cell to discriminate between self and non-self RNAs. We showed that the Adar1-/-embryo is dead by day E12.5 as it lacks hematopoietic progenitor cells and has elevated interferon levels. However this mutant can be rescued by a mutation in Mavs-/- demonstrating that Adar1 is an essential component of the innate immune pathway.
There are over 140 different types of RNA modification so we propose that RNA modifications other that inosine play a role in the innate immune response. Therefore we want to isolate and identify different classes of RNAs (not tRNAs and rRNAs) which are enriched in RNA modification, investigate their biological functions if their levels change in autoimmune disorders.
list / cards
Name and position |
Phone |
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Mary Anne O'Connell, Ph.D. ERA CHAIR |
+420 54949 5460 | |
Liam Keegan, Ph.D. Principal Investigator |
+420 54949 5460 | |
Květoslava Brožinová odborná pracovnice |
+420 54949 5651 | |
Dragana Vukić, M.Sc. odborná pracovnice - PhD student |
+420 54949 5651 | |
Anzer Khan, M.Sc. odborný pracovník - PhD student |
+420 54949 5651 | |
Nagraj Sambrani, PhD odborný pracovník ve výzkumu - postdoc |
+420 54949 8505 | |
Veronika Martínková odborná pracovnice |
+420 54949 4197 | |
David Michalík |
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Ketty Sinigaglia odborná pracovnice - PhD student |
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Jiří Sedmík odborný pracovník - PhD student |
+420 54949 8505 | |
Dagmara Marta Wiatrek-Moumoulidis odborná pracovnice ve výzkumu - postdoc |
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Pavla Linhartová odborná pracovnice |
+420 54949 4259 | |
Stanislav Stejskal odborný pracovník |
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Petra Vrbická chovatelka laboratorních zvířat |
29. ledna 2018 9:46
LECTURE: Dr. Ondrej Hovorka: Models of magnetic nanoparticles for biomedical applications
25. ledna 2018 18:21
WHEN: 30. 01. 2018 WHERE: CEITEC BUT, Purkynova 123, large meeting room SPEAKER: Dr Andriy Marko TALK: Advances in PELDOR…