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Advanced Nano and Microtechnologies Advanced Materials Structural Biology Gen. and Prot. of Plant Systems Molecular Medicine Brain and Mind Research Molecular Vet. Medicine

Developmental and Cell Biology of Plants - Tomasz Nodzynski

Research Group Leader
Phone: +420 54949 8420
E-mail:
Office:

Research areas

Plants as sessile organisms must adapt to ever changing environmental conditions. The adaptations to environmental cues are essential for plant survival and consequently for crop productivity. The adaptation processes rely on sensing and transduction of environmental signals, integration of various forms of signals and determination of the final response. Plant hormones are implicated in various aspects of regulation of plant development, growth and responses to environmental cues. Our work is focused on systematic analysis of environmental and hormonal signaling in regulating plant growth and development, as well as adaptation to environmental cues.

We focus on how different environmental and endogenous signals are integrated into the subcellular dynamics and polar localisation of transporters for plant hormone auxin. We expect to get a deeper knowledge on plasticity of plant responses to environmental cues.

Main objectives

1. Plant hormonal signalling for regulation of cell polarity and subcellular dynamics:

Identification of key entry points by which auxin and other signalling pathways modulate subcellular dynamics and polar trafficking of PIN auxin transporters

2. Cell polarity and subcellular dynamics in plant cells:

We elucidate molecular and cellular mechanisms underlying cell polarity and trafficking processes by combination of genetics and high resolution microscopy approaches.

3. Perception of external signals and their integration into subcellular dynamics and cell polarity:

Using combination of reverse genetic, chemical genomics, life cell and high-resolution imaging approaches; we gain new insights into how gravity and light perception is integrated into regulation of subcellular dynamics.

4. Integration of hormonal signalling and subcellular dynamics for multicellular tissue development by mathematical modelling:

The acquired knowledge on hormonal networks; processes of subcellular dynamics and integration of different signals will be used to mathematically model these processes and to extrapolate them onto multicellular developmental situations.

list / cards

Name and position

E-mail

Phone

Tomasz Nodzynski, Ph.D.
Research Group Leader
+420 54949 8420
Sibu Simon, Ph.D.
Research specialist - postdoc
+420 54949 3699
Marta Zwiewka, Ph.D.
Research specialist - postdoc
+420 54949 8419
Nikola Rýdza
Research specialist - PhD student
Lilla Koczka
odborná pracovnice - PhD studentka
Sravankumar Thula
Research specialist - PhD student
Vendula Pukyšová
Research specialist - PhD student
Adria Sans Sánchez
Research specialist - PhD student
Stanislava Sladeček
laborantka
Andrea Simeunovic
Research specialist - postdoc
Yewubnesh Seifu Wendimu
odborná pracovnice - PhD studentka

SELECTED PUBLICATIONS

2016

  • BALLA, J; MEDVED'OVA, Z; KALOUSEK, P; MATIJESCUKOVA, N; FRIML, J; REINOHL, V; PROCHAZKA, S, 2016:Auxin flow-mediated competition between axillary buds to restore apical dominance. SCIENTIFIC REPORTS 6
  • NODZYNSKI, T; VANNESTE, S; ZWIEWKA, M; PERNISOVA, M; HEJATKO, J; FRIML, J, 2016:Enquiry into the Topology of Plasma Membrane-Localized PIN Auxin Transport Components. MOLECULAR PLANT 9 (11), p. 1504 - 1519.
  • PERNISOVA, M; PRAT, T; GRONES, P; HARUSTIAKOVA, D; MATONOHOVA, M; SPICHAL, L; NODZYNSKI, T; FRIML, J; HEJATKO, J, 2016:Cytokinins influence root gravitropism via differential regulation of auxin transporter expression and localization in Arabidopsis. NEW PHYTOLOGIST 212 (2), p. 497 - 509.
  • SIMON, S; SKUPA, P; VIAENE, T; ZWIEWKA, M; TEJOS, R; KLIMA, P; CARNA, M; ROLCIK, J; DE RYCKE, R; MORENO, I; DOBREV, PI; ORELLANA, A; ZAZIMALOVA, E; FRIML, J, 2016:PIN6 auxin transporter at endoplasmic reticulum and plasma membrane mediates auxin homeostasis and organogenesis in Arabidopsis. NEW PHYTOLOGIST 211 (1), p. 65 - 74.
  • ZHU, JS; BAILLY, A; ZWIEWKA, M; SOVERO, V; DI DONATO, M; GE, P; OEHRI, J; ARYAL, B; HAO, PC; LINNERT, M; BURGARDT, NI; LUCKE, C; WEIWAD, M; MICHEL, M; WEIERGRABER, OH; POLLMANN, S; AZZARELLO, E; MANCUSO, S; FERRO, N; FUKAO, Y; HOFFMANN, C; WEDLICH-SOLDNER, R; FRIML, J; THOMAS, C; GEISLER, M, 2016:TWISTED DWARF1 Mediates the Action of Auxin Transport Inhibitors on Actin Cytoskeleton Dynamics. PLANT CELL 28 (4), p. 930 - 948.

2015

  • GRONES, P; FRIML, J, 2015:ABP1: Finally Docking. MOLECULAR PLANT 8 (3), p. 356 - 358.
  • GRONES, P; CHEN, X; SIMON, S; KAUFMANN, WA; DE RYCKE, R; NODZYNSKI, T; ZAZIMALOVA, E; FRIML, J, 2015:Auxin-binding pocket of ABP1 is crucial for its gain-of-function cellular and developmental roles. JOURNAL OF EXPERIMENTAL BOTANY 66 (16), p. 5055 - 5065.
  • ROBERT, HS; GRUNEWALD, W; SAUER, M; CANNOOT, B; SORIANO, M; SWARUP, R; WEIJERS, D; BENNETT, M; BOUTILIER, K; FRIML, J, 2015:Plant embryogenesis requires AUX/LAX-mediated auxin influx. DEVELOPMENT 142 (4), p. 702 - 711.
  • ZWIEWKA, M; NODZYNSKI, T; ROBERT, S; VANNESTE, S; FRIML, J, 2015:Osmotic Stress Modulates the Balance between Exocytosis and Clathrin-Mediated Endocytosis in Arabidopsis thaliana. MOLECULAR PLANT 8 (8), p. 1175 - 1187.

2014

  • BAILLY, A; WANG, BJ; ZWIEWKA, M; POLLMANN, S; SCHENCK, D; LUTHEN, H; SCHULZ, A; FRIML, J; GEISLER, M, 2014:Expression of TWISTED DWARF1 lacking its in-plane membrane anchor leads to increased cell elongation and hypermorphic growth. PLANT JOURNAL 77 (1), p. 108 - 118.
  • CHEN, YN; AUNG, K; ROLCIK, J; WALICKI, K; FRIML, J; BRANDIZZI, F, 2014:Inter-regulation of the unfolded protein response and auxin signaling. PLANT JOURNAL 77 (1), p. 97 - 107.
  • NARAMOTO, S; NODZYNSKI, T; DAINOBU, T; TAKATSUKA, H; OKADA, T; FRIML, J; FUKUDA, H, 2014:VAN4 Encodes a Putative TRS120 That is Required for Normal Cell Growth and Vein Development in Arabidopsis. PLANT AND CELL PHYSIOLOGY 55 (4), p. 750 - 763.
  • SAUER, M; FRIML, J, 2014:Plant Biology: Gatekeepers of the Road to Protein Perdition. CURRENT BIOLOGY 24 (1), p. R27 - R29.
  • XU, TD; DAI, N; CHEN, JS; NAGAWA, S; CAO, M; LI, HJ; ZHOU, ZM; CHEN, X; DE RYCKE, R; RAKUSOVA, H; WANG, WY; JONES, AM; FRIML, J; PATTERSON, SE; BLEECKER, AB; YANG, ZB, 2014:Cell Surface ABP1-TMK Auxin-Sensing Complex Activates ROP GTPase Signaling. SCIENCE 343 (6174), p. 1025 - 1028.

2013

  • COVANOVA, M; SAUER, M; RYCHTAR, J; FRIML, J; PETRASEK, J; ZAZIMALOVA, E, 2013:Overexpression of the Auxin Binding PROTEIN1 Modulates PIN-Dependent Auxin Transport in Tobacco Cells. PLOS ONE 8 (7)
  • ROBERT, HS; GRONES, P; STEPANOVA, AN; ROBLES, LM; LOKERSE, AS; ALONSO, JM; WEIJERS, D; FRIML, J, 2013:Local Auxin Sources Orient the Apical-Basal Axis in Arabidopsis Embryos. CURRENT BIOLOGY 23 (24), p. 2506 - 2512.
  • SIMON, S; KUBES, M; BASTER, P; ROBERT, S; DOBREV, PI; FRIML, J; PETRASEK, J; ZAZIMALOVA, E, 2013:Defining the selectivity of processes along the auxin response chain: a study using auxin analogues. NEW PHYTOLOGIST 200 (4), p. 1034 - 1048.
  • WABNIK, K; ROBERT, HS; SMITH, RS; FRIML, J, 2013:Modeling Framework for the Establishment of the Apical-Basal Embryonic Axis in Plants. CURRENT BIOLOGY 23 (24), p. 2513 - 2518.

2011

  • WABNIK, K; KLEINE-VEHN, J; GOVAERTS, W; FRIML, J, 2011:Prototype cell-to-cell auxin transport mechanism by intracellular auxin compartmentalization. TRENDS IN PLANT SCIENCE 16 (9), p. 468 - 475.

GRANTY

  • Genetic elucidation of molecular mechanisms underlying cell polarity and auxin transport in plants (GA13-40637S), Czech Science Foundation - Standard Grants, 2013 - 2017
  • Multi-disciplinary approach in strigolactone research to battle crop infestation by parasitic Striga sp (5SA14534), South Moravian Region - SoMoPro, 2016 - 2019
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